Monthly Archives: December 2012

#Lyme Disease and the Methylation Cycle

I’m feeling better than I was last week. My intense detox has subsided, and I’ve resumed my usual relentless research of this miserable illness. Here is yet another piece.

The importance of repairing the methylation cycle in treating Lyme Disease.

Lyme Disease may start out as an infection, but left untreated, it causes many systemic imbalances and deficiencies in the body. Effective treatment of LD must include both antimicrobial therapy and support/repair of a number of the body’s systems. The methylation cycle is one of those systems that becomes impaired by LD.

What is the Methylation Cycle?

The methylation cycle is a biochemical cycle that’s involved in many of the body’s functions. When the cycle is broken, important functions are impaired. In particular, glutathione (our body’s master anti-oxidant and detox agent) is depleted. Rich van Konynenburg, Ph.D., an independent researcher who has done much research on ME/CFS syndromes, believes that glutathione depletion causes many of the problems in ME/CFS. Other prominent LLMD’s, such as Dietrich Klinghardt, also believe that this cycle must be functioning before recovery from Lyme Disease is possible.

Dr. van Konynenburg identified a number of functions involved in the methylation cycle:

  • To produce vital molecules such as Co Q-10 and carnitine.
  • To switch on DNA and switch off DNA. Note: When viruses attack our bodies, they take over our own DNA in order to replicate themselves. Disability of this function makes us more susceptible to viral infection.
  • To produce myelin for the brain and nervous system.
  • To control the liver’s synthesis of glutathione (essential for detoxification).
  • To control the sulphur metabolism of the body, (also important for detoxification).
  • As part of folic acid metabolism.

If the methylation cycle doesn’t work, the immune system, the detoxification system, and the anti-oxidant system all mal-function. Consequently, our body’s ability to repair is reduced.

A great website for information on ME/CFS (Myalgic Encephalomyelitis and Chronic Fatigue Syndrome) and Dr. van Konyenburg’s research is  Also see

Here is a fairly simple diagram on the Methylation Cycle from the Linus Pauling Institute

Methylation Cycle from the Linus Pauling Institute

Dr. Amy Yasko is another pioneer in methylation research and its role in autism. Here is a diagram from her website that helps illustrate the functions of the methylation cycle:

methylation diagram Yasko

Deficiency of this system is now implicated in autism, chronic fatigue syndrome, Hepatitis C, Gulf War Syndrome, and in Lyme Disease. Perhaps this is a factor in many illnesses we do not yet understand.


The cornerstones of treatment are detoxification and specific nutrients:

  • activated forms of vitamins B12
  • activated folic acid (folate)
  • glutathione
  • phosphatidyl serine

My doctor has me on moderate doses of methylated B12 and methylfolate to start, as well as L-carnitine and Co Q 10 for energy. Recently, my energy has increased (I no longer need a nap every day) and I no longer need a thyroid supplement. Starting slowly is key, as repairing the methylation cycle puts the immune system back “on line”, which can lead to intense detox/die off reactions.

Once again, we find another piece of the already complicated puzzle of Lyme Disease.


#Lyme Disease, Pain, and Despair

Hello Again to All,

I am in pain. Burning, unrelenting pain that extends from my middle back, into my shoulders, across my chest, up to the trapezoid muscles, up my neck, and surrounds my head. The headache is non-stop, despite prescription pain meds. I’m nauseated and fatigued. What is happening to me? I’m once again treating bartonella, that’s what.

I went through an unexpected and intense detox reaction in August and September after taking TWO drops of Byron White A-BART. I sailed though previous treatments with BW A-L Formula and A-BAB Formula. I felt great for several months in the spring and summer. And then I hit the proverbial wall. So I guess we have found my dominant infection. Which is a good thing, right? But how do I get through this? I can’t go around it. I must go through it. But how? For starters, I’m in full detox mode. For me this means omitting anything challenging to my body.

  • Stop/reduce intense detox and anti-microbial meds and supplements.
  • Use anti-inflammatories and supportive treatments, such as Quercetin, Meriva, Vitamin C.
  • Follow a liquid diet with vegan protein/fruit shakes and broths with well-cooked veggies if I tolerate them.
  • Do gentle detox, like extra coffee enemas, as needed.
  • Get a BioSET treatment to help my body cope.

These all help bring down the inflammation for me.

I have prescription pain meds to help take the edge off, but they leave me dopey and sleepy. I wind up padding aimlessly around the house, lying on the couch, being generally unproductive and feeling worthless. Then the fear sets in and I become a ball of insecurity. How am I supposed to go to work like this? How can I take care of the house? We’re going to run out of money if I can’t work. I can’t afford my medical bills, let alone all the other life expenses. Who would want to be around me? Who could love me like this? Ugh.

I rarely write about the emotional side of this illness. That’s because I rarely deal with it. I don’t deal well with anger, suffering, and pain. I don’t cry much. I bury my emotions and wear my repression like a badge of honor. I don’t complain. I’m in control, which means I must be strong, right?

I’ve done my share of therapy, and I still have a hard time releasing. I can squeeze out a couple of tears now and then, but a full-on good cry is rare. I just walk around in a state of semi-depression without the ability to engage the emotions on the far ends.

Is there a relationship between the emotional and physical inability to detox? Can you teach your body to detox better, or is it a genetic determination? How does one learn how to cry? By watching sad movies and bringing it on by catharsis? Any suggestions are appreciated. For now, I’m just trying to hang in there.


#Lyme Disease and Gum Infections

Hello Dear Readers,

Those of you who read my earlier posts may remember my problem with an infected gum and painful tooth. To recap, I developed an angry, red, swollen gum around a lower tooth last winter. My dentist did a deep cleaning which aggravated the tooth and sent me into a systemic flare up for a week. He thought the tooth was being rejected by my body and sent me to specialists. The endodontist thought I might need a root canal ($1,100). The periodontist wanted to cut out the bad gum tissue ($1,500). The oral surgeon said the tooth needs to be extracted and offered an implant ($5,000).

After doing some research, I learned that Borrelia and other Lyme related organisms are frequently found in gum tissue. Though I was in quite a bit of pain, I decided to try less invasive solutions.

A cold laser treatment and BioSET treatment ended the pain but the infection remained. I tried chlorohexadrine solution, hydrogen peroxide, neem bark, oregano oil, and salt water, all to no avail.

Then I came across a website from a Ray Behm, DDS, a holistic dentist who offered a simple, cheap solution to gum infections: Baking soda, sea salt, and peroxide forced deeply into the gum sulcus with a soft, small brush, 2x per day for 2 weeks. I followed his instructions and guess what? The infection is gone! Here is his Healthy Gum protocol in a nutshell:

Combine these two dry ingredients in a small jar with a lid:

  1. Three parts baking soda
  2. One part natural salt or Parkelp

Shake this dry mixture to blend well. Keep this dry mixture in your bathroom. You will be using this every day.

Daily use:

Pour 1 tsp of DRY mixture from the container into your palm or dish. Add one of the following

  • Colloidal Silver – safe if you still have mercury amalgam fillings, or
  • Hydrogen peroxide – only if you have no metal (mercury/amalgam) fillings in your mouth, or
  • Aloe Vera

Adding such products as Amazon Herb’s Una de Gato (an herb also used to treat Lyme Disease!) will help too.

1.  Load a bunch of the mixture onto the soft brush. Angle the brush 45 degrees to where the tooth meets the gum (the sulcus junction).

2.  Push the loaded brush as far as you can into the area where the tooth meets the gum (sulcus). Do not cause yourself pain.

3.  Use a vibrating motion (very small wiggling motion) so that the bristles that are forced into the sulcus remain there as you vibrate.  Do not use wide circular motions like scrubbing a floor or washing a window. Repeat this action as you move along the gum line for three to five seconds at each spot on both the cheek and tongue side.  Repeat this procedure until you have completed both upper and lower gum lines. Whenever necessary spit out the mixture and saliva. There is no need to rinse afterwards, unless you want to.

The soft brush is the applicator/loading instrument that is used to get the recipe into the sulcus. The recipe does the work, not the brush; the brush forces the recipe into the sulcus.

Doing the above on a gradient approach will obtain healing in the sulcus. Do it once a day until you can gradually increase to twice a day. When you are able to do it twice a day for two weeks in a row, your gums should have become very tough (this is good) and should have a pink-white color (this is also good).

That’s it! Please be sure to visit Dr. Behm’s informative website: He understands the importance of amalgam-free dentistry and all the microorganisms (including spirochetes!) that can infect the gums, impact our systemic health, and lead to tooth loss. Hurray for Dr. Behm!

And hurray for small victories! I’ll take all that I can get.

– Laura