Category Archives: methylation

Renewed Hope for Lyme Disease and Biotoxin Illness

Hello to All,

I met with my third doctor in three years on my ongoing quest for health. I was impressed by his comprehensive approach to my illness. Here is the gist of it:

  • I have Lyme Disease (he is my third doc to confirm this*) AND
  • I also have Babesia (diagnosed by symptoms. Testing is $$$ and not always helpful) AND
  • Poor phase 1 and 2 detoxification ability resulting in inadequate glutathione production
  • Inability to detox mold resulting in biotoxin illness (revealed by genetic testing)
  • Methylation defects – MTFHR and others
  • Ongoing yeast problems
  • Increased intestinal permeability (aka Leaky Gut syndrome)
  • High levels of lead and mercury (though they came down significantly with IV chelation)
  • Reduced liver function
  • Reduced thyroid and adrenal function

Now, I already knew most of this, but it’s refreshing to have someone put it all together at one time. Now we’ll see if he has solutions for my problems. I can only hope that this is the complete picture of my health problems and there are no others in hiding. I’m testing my metal levels and spending the next 5 weeks detoxing before proceeding with Babesia treatment. Here are a few meds and supplements that I’ll be adding to my regimen:

  • Apex Methyl-SP formula, containing high doses of B vitamins, TMG and choline (given by my current naturopath)
  • Researched Nutritionals Liposomal Glutathione
  • Cholestyramine
  • Diflucan every other day
  • Nystatin twice per day

I’m also experimenting with my diet. I mostly avoid gluten, dairy, and sugar, and now I’m cutting down on the meat and omitting beef and pork entirely. I must admit, I feel a little starved.

I feel a renewed sense of hope after meeting with him. But as they say, the proof of the pudding is in the eating. I’ll track my symptoms and report back.



* Note: I have a Lyme Disease diagnosis by two naturopaths and an MD whose specialty is treating Lyme, ME/CFS and similar conditions. I’ve thought about seeing an infectious disease doc, but I doubt I’ll get any assistance from one. My diagnosis does not meet CDC criteria.

#Lyme Disease and the Methylation Cycle

I’m feeling better than I was last week. My intense detox has subsided, and I’ve resumed my usual relentless research of this miserable illness. Here is yet another piece.

The importance of repairing the methylation cycle in treating Lyme Disease.

Lyme Disease may start out as an infection, but left untreated, it causes many systemic imbalances and deficiencies in the body. Effective treatment of LD must include both antimicrobial therapy and support/repair of a number of the body’s systems. The methylation cycle is one of those systems that becomes impaired by LD.

What is the Methylation Cycle?

The methylation cycle is a biochemical cycle that’s involved in many of the body’s functions. When the cycle is broken, important functions are impaired. In particular, glutathione (our body’s master anti-oxidant and detox agent) is depleted. Rich van Konynenburg, Ph.D., an independent researcher who has done much research on ME/CFS syndromes, believes that glutathione depletion causes many of the problems in ME/CFS. Other prominent LLMD’s, such as Dietrich Klinghardt, also believe that this cycle must be functioning before recovery from Lyme Disease is possible.

Dr. van Konynenburg identified a number of functions involved in the methylation cycle:

  • To produce vital molecules such as Co Q-10 and carnitine.
  • To switch on DNA and switch off DNA. Note: When viruses attack our bodies, they take over our own DNA in order to replicate themselves. Disability of this function makes us more susceptible to viral infection.
  • To produce myelin for the brain and nervous system.
  • To control the liver’s synthesis of glutathione (essential for detoxification).
  • To control the sulphur metabolism of the body, (also important for detoxification).
  • As part of folic acid metabolism.

If the methylation cycle doesn’t work, the immune system, the detoxification system, and the anti-oxidant system all mal-function. Consequently, our body’s ability to repair is reduced.

A great website for information on ME/CFS (Myalgic Encephalomyelitis and Chronic Fatigue Syndrome) and Dr. van Konyenburg’s research is  Also see

Here is a fairly simple diagram on the Methylation Cycle from the Linus Pauling Institute

Methylation Cycle from the Linus Pauling Institute

Dr. Amy Yasko is another pioneer in methylation research and its role in autism. Here is a diagram from her website that helps illustrate the functions of the methylation cycle:

methylation diagram Yasko

Deficiency of this system is now implicated in autism, chronic fatigue syndrome, Hepatitis C, Gulf War Syndrome, and in Lyme Disease. Perhaps this is a factor in many illnesses we do not yet understand.


The cornerstones of treatment are detoxification and specific nutrients:

  • activated forms of vitamins B12
  • activated folic acid (folate)
  • glutathione
  • phosphatidyl serine

My doctor has me on moderate doses of methylated B12 and methylfolate to start, as well as L-carnitine and Co Q 10 for energy. Recently, my energy has increased (I no longer need a nap every day) and I no longer need a thyroid supplement. Starting slowly is key, as repairing the methylation cycle puts the immune system back “on line”, which can lead to intense detox/die off reactions.

Once again, we find another piece of the already complicated puzzle of Lyme Disease.