Hello to All,
As I mentioned in an earlier post, I had genetic testing done in the spring. My doctor had me do the Gene SNP test which costs about $275.00. I’ll share the pertinent results with you.
Genes with impact:
- B Vitamin Metabolism: MTHFR, MTR, MTRR
- Phase 1 Detoxification: CYP 1A2*1F (deletion)
- Phase 2 Detoxification: GSTM1, GSTT1 (deletion)
- Antioxidant Function: PON 1, SOD 2
- Bone Density: VDR
- Glucose Balance: ACE, IL6, LIPC, PON1, PPARg, PPARGC1A, VDR, ADRB2
- Inflammatory Response: IL6
- Salt Sensitivity: AGT
- Alcohol Metabolism: ADH1C
I feel that this is an important test for me. It confirms what I already knew were some problem areas, alerts me to potential problems, and guides my lifestyle and Lyme Disease treatment.
In terms of nutrition: I need to take methylated B vitamins for the rest of my life, such as folate, P5P, and B12. I need extra vitamin D and plenty of antioxidants. Luckily, I eat loads of fresh vegetables.
In terms of avoidance, I need to watch my salt and sugar (which I already do). And no more drunken shenanigans! ADH1C controls alcohol dehydrogenase. Darn. And interestingly enough, there is a connection between candida toxins and alcohol toxins – a waste product called acetaldehyde. This may be a key to candida treatment for me. I’ll report more on that later.
I have IL-6 problems. Interleukin 6 acts as both a pro-inflammatory and anti-inflammatory cytokine (immunoregulatory protein that affects inflammation). In patients with Lyme neuroborreliosis, inflammation and symptoms of fatigue and malaise occur out of proportion to the relatively low number of spirochetes present. Previous studies have identified interleukin-6 (IL-6) as a candidate molecule for amplification of CNS inflammation in this disease (http://www.neurology.org/content/49/1/147.abstract). This means I need to find safe substances that control this particular inflammatory pathway.
And here’s the biggie: I completely lack the genes for Phase 1 and 2 detoxification. I possess neither. Nada. Pas de tout. Geen (Dutch). This is a big problem. In fact, this is probably the underlying reason some people get chronic Lyme Disease, and other people have numerous tick bites with no symptoms, or have a brief illness. I’m one of those unfortunate people who can’t get rid of infectious agents and toxins. My liver cannot make enough glutathione (a major antioxidant and detox agent). I will have to manually detox for the rest of my life to become and remain healthy.
This confirms my theory that my illness is like a perfect storm: exposure to bacteria and viruses, lowered immune response, exposure to mold, elevated stress, inadequate (American processed food) diet + genetic predispositions = chronic, debilitating illness.
So, detox, detox, and more detox. This will be the crux of successful treatment for me. Finding substances to kill the infections of borrelia, babesia, bartonella, and candida is not hard. Getting good nutrition is not hard (for me). But helping my body to dispose of the waste is proving to be a great challenge. I already use saunas, epsom salt baths, coffee enemas, activated charcoal, homeopathic and herbal drainage remedies, curcumin, etc… And that’s not enough, for heaven’s sake!
Whew! That was a lot of information to process. But I feel an even deeper understanding of my problems that ever. I meet with my doctor again in July and we will formulate my next plan of attack.